The acute lethal dose 50 (LD50) of caffeine in albino rats
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Median lethal dose (LD50) estimation of β-cyfluthrin in male and female Swiss albino mice
Present study was undertaken to determine the median lethal dose (LD50) of β-cyfluthrin (β-cyf), a synthetic (type II) pyrethroid pesticide in male and female Swiss albino mice. The calculation of LD 50 is an initial screening step in the assessment and evaluation of the toxic characteristic of a chemical substance. The selected single doses of β-cyfluthrin based on the pilot study were 200, 22...
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Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to a safe seafood level for TTX, oral toxicity data are required. In this study, a 4-level Up and Down Procedure was designed in order to determi...
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Background: Acrylamide (C3H5NO) is a vinyl monomer. This water-soluble crystalline solid is a colorless, odorless agent which is used in scientific laboratories and some industries. Acrylamide has cellular oxidative effects. Acute or chronic poisoning with this agent happens as a result of skin, respiratory, or oral contacts. Clinical manifestations depend on the dose, duration, and frequency...
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Foeniculum vulgare Miller, (fennel) (Umbelliferae) is an annual, biennial or perennial aromatic herb, depending on the variety, and has been known since antiquity in Europe and Asia Minor. The leaves, stalks and seeds (fruits) of the plant are edible1. Extracts of the Foeniculum vulgare Miller (fennel) seeds are used in traditional Turkish medicine as an anti-inflammatory agent 2. The anti-infl...
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Background: Methyl 2-benzimidazole carbamate (carbendazim) is a synthetic fungicide used against organisms that cause different types of plant diseases. It is widely used as a preservative in leather, paint, textile, fruit, and paper industry. It is also used as an anticancer drug in clinical medicine. Methods: To evaluate the low dose toxicity of this compound in mammalian tissues, carbend...
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ژورنال
عنوان ژورنال: Regulatory Toxicology and Pharmacology
سال: 2016
ISSN: 0273-2300
DOI: 10.1016/j.yrtph.2016.07.011